53 articles - From Friday Dec 12 2025 to Friday Dec 19 2025
Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…
| Liver Transpl |
|---|
| AASLD AST Practice Guideline on adult liver transplantation: Diagnosis and post-transplant management of non-graft-related complications.
Multidisciplinary care and partnership between the transplant center and the primary care physician is essential for long-term care of the transplant recipient. Significant components of non-graft management guidelines are derived from retrospective cohort studies, systematic reviews and extrapolation of data from the general population. This gap highlights the unmet need for robust prospective studies addressing long-term care of liver transplant recipients. |
| Living liver donor safety: Early postoperative considerations of living liver donation guidelines from the ILTS-iLDLTG consensus conference.
Structured clinical and psychosocial follow-up protocols, perioperative prophylaxis for surgical site infections and venous thromboembolism, and management of early biliary and vascular complications are discussed. These may help standardize care, reduce complications and improve short-term outcomes in LLD. |
| Long term considerations following living liver donation - guidelines from the 2025 ILTS-iLDLT consensus conference on living liver donor safety.
The 2025 International Liver Transplantation Society and International Living Donor Liver Transplantation Society (ILTS-iLDLT) Consensus Conference convened experts in the field of liver transplantation to establish evidence-based guidelines focused on the long-term medical, psychological and social considerations following living liver donation. The aim of this working group was to integrate current evidence and expert consensus on donor follow-up protocols, risk assessment and management strategies to promote long term donor health, quality of life and living liver donor programs globally in order to safeguard the welfare of this unique population. |
| Pancreas |
| Updates from the 2025 IAP Acute Pancreatitis Guidelines. |
meta-analyses and systematic reviews
| Pancreas |
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| Post-Endoscopic Retrograde Cholangiopancreatography Pancreatitis Prophylaxis: Does the Choice of Crystalloid Fluid Matter? A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
At equivalent fluid administration rates, using LR compared to NS showed a significant risk reduction in PEP of 4% with a number needed to treat (NNT) of 25. LR may be the better crystalloid for ERCP. Further studies are needed to validate these results. |
| Risk Prediction Models for Post-Endoscopic Retrograde Cholangiopancreatography Pancreatitis: A Systematic Review and Meta-Analysis.
Existing PEP prediction models demonstrate overall good discrimination but are limited by methodological heterogeneity and scarce external validation. Clinically, validated models can support risk stratification to guide preventive strategies (e.g., rectal NSAIDs, aggressive hydration, selective prophylactic pancreatic stenting) alongside clinical judgment. Future research should prioritize multicenter prospective validation, robust calibration and decision-curve analyses, impact assessments, and explainable machine learning models integrated with electronic health record systems. |
| Pancreatology |
| Efficacy and safety of pregabalin in managing pain of chronic pancreatitis: A systematic review and meta-analysis of randomized controlled trials. |
RCT, clinical trials, retrospective studies, etc…
| Am J Clin Nutr |
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| Effects of Replacing Solid Fats and Added Sugars with Avocado in Adults with Elevated Cardiometabolic Risk: A Randomized, Double-Blind, Controlled Feeding, Crossover Trial.
Replacing solid fats and added sugars with avocado in a typical American diet improved the lipoprotein lipid profile in adults with elevated TG. as NCT04990817 ( |
| Plant-based diets, gut microbiota, blood metabolome, and risk of colorectal, liver and pancreatic cancers: results from a large prospective cohort study of predominantly low-income Americans.
A diet high in healthy plant foods and low in animal foods was inversely associated with liver cancer risk and with CRC risk among screening-naïve participants. These associations may be partly mediated through gut microbiota and systemic metabolism. |
| Vegetarian diet and likelihood of becoming centenarians in Chinese adults aged 80 years or older: a nested case-control study.
Targeting individuals of advanced age (80+ years) in China, we found that individuals following vegetarian diet had lower likelihood of becoming centenarians relative to omnivores, underscoring the importance of a balanced high-quality diet with animal- and plant-derived food composition for exceptional longevity, especially in the underweight oldest-old. |
| Inflamm Bowel Dis |
| Characterizing Healthcare Disparities, Utilization, and Trends of Inflammatory Bowel Disease in Transgender and Nonbinary Patients: A Population-Based Study.
TGNB IBD patients experience greater gastrointestinal and psychiatric comorbidities and receive fewer interventions overall despite greater healthcare contact. HRT was not associated with worsening disease or complications. These findings highlight critical disparities and the need for further research in this population. |
| Sustained Clinical Remission Following a Second Autologous Hematopoietic Stem Cell Transplantation for Refractory Crohn Disease.
At 30 months following the second autologous hematopoietic stem cell transplantation, the patient remains in sustained clinical and endoscopic remission off al immunosuppressive and biologic medications. This case documents the feasibility and favorable long-term outcome of a second non-myeloablative autologous hematopoietic stem cell transplantation, suggesting this approach may be a valid and effective salvage option for highly selected patients with severe, refractory Crohn disease. |
| Trends in Use of Prescribed Opioids in Incident and Prevalent Patients With Ulcerative Colitis: A Nationwide Study in Sweden.
In this nationwide register-based study, adults with UC had higher prescribed opioid use within two years before and up to five years after first UC diagnosis compared with reference individuals. However, adults with prevalent UC (and reference individuals) had a declining temporal opioid use trend during 2006-2022. |
| J Crohns Colitis |
| HLA-DQA1*05:01 and DQA1*05:05 inform choice of anti-tumor necrosis factor and concomitant use of immunomodulators in patients with inflammatory bowel disease.
Our findings highlight distinct associations between HLA-DQA1*05 allele subtypes and time to LoR of infliximab and adalimumab in IBD-treated patients. The protective effect of immunomodulator use is allele-specific for adalimumab. These results provide a rationale for incorporating HLA testing into personalized anti-TNF management to optimize treatment durability. |
| Risk of serious infections in patients with inflammatory bowel disease treated with biologic and small molecule therapies: A nationwide cohort study.
Patients with IBD were at an increased risk of infections, even among those naïve to IMM and advanced therapies. There was no significant difference in risk of infections across advanced therapy exposures. |
| Liver Transpl |
| Assessment of sarcopenia in cirrhosis: A practical approach using thigh and psoas ultrasound, bioimpedance, and anthropometry.
Non-radiating tools, such as US-based thigh and psoas measurements, BIA-derived BPI, and anthropometry, are accurate alternatives to CT for detecting sarcopenia in patients with cirrhosis. These tools are simple, safe, and reproducible, which supports their integration into routine clinical practice for sarcopenia screening and monitoring. |
| Defining weight trajectory after liver transplantation using generative artificial intelligence.
Using a novel statistical approach (GenAI), we identified key weight gain trajectories in LT recipients to be incorporated into clinical practice for risk stratification and mitigation. |
| Reconditioning steatotic liver grafts: Advances in pharmacological defatting approaches for expanding the donor pool.
These interventions have the potential to address the challenges posed by hepatic steatosis, improve graft quality, expand the availability of transplantable livers, and enhance clinical outcomes of transplant candidates. Finally, we highlight current limitations and outline directions for future research and clinical applications. |
| Severity of liver disease is associated with cirrhotic cardiomyopathy: A multicenter study.
Among patients with cirrhosis who were LT candidates, severity of liver disease was positively associated with the presence of CCM and its echocardiographic features. These data may inform patient selection and encourage early detection of CCM among patients with cirrhosis. |
| The survival benefit of deceased donor liver transplantation using MELD 3.0: A contemporary analysis.
However, MELD 3.0 alone does not capture the full complexity of LT candidacy. Factors such as refractory ascites, hepatic encephalopathy, frailty, and poor quality of life should also be considered when considering LT for the individual patient. |
| Pancreas |
| Assessment of Skeletal Muscle Quality via Intramuscular Adipose Tissue Content Predicts Surgical Morbidity and Prognosis after Pancreatoduodenectomy.
IMAC, an indicator of skeletal muscle quality, provides convenient and highly valuable diagnostic information on body composition and predicts postoperative complications and prognosis in patients with malignant tumors undergoing PD. |
| Association Between Social Determinants of Health and the Risk of Acute Pancreatitis and Related Diseases: A Prospective Cohort Study in the UK Biobank.
Social disadvantage, as reflected by higher SDH scores, is associated with high risk of AP and AP-related diseases. These findings underscore the importance of considering social context in clinical and public health efforts to reduce the burden of pancreatic diseases. |
| Characteristics of Pancreatic Cancer-Associated Ascites and Redefined Criteria for Bacterial Peritonitis.
PDAC-associated ascites exhibited distinct characteristics according to their etiology. Redefined diagnostic criteria could aid in a more specific diagnosis of bacterial peritonitis in patients with PDAC. |
| Clinical Characteristics of Chronic Pancreatitis Patients Presenting With Acute Pancreatitis, Abdominal Pain, or Primary Painless Disease.
Pain-only presentations are seen in 20% of patients with definite CP. Age of disease onset and etiology have a significant impact on the clinical presentation of CP patients. |
| Feeding Tube Placement in Nutritionally At-risk Patients Undergoing Pancreaticoduodenectomy: A Propensity Score-matched Analysis.
In nutritionally at-risk patients undergoing pancreaticoduodenectomy, the risks of feeding tube placement appear to outweigh the benefits, as no reduction in complications was observed and morbidity was increased. |
| Internet-delivered Cognitive-behavioral Intervention for Pain in Pediatric Acute Recurrent and Chronic Pancreatitis: A Multicenter Randomized Controlled Trial.
This is the first trial to evaluate the feasibility, acceptability, and preliminary efficacy of internet-delivered CBT for pediatric pancreatitis pain demonstrating strong feasibility and treatment acceptability. Due to under-enrollment, the trial had reduced statistical power. Future research with a larger sample may build on these findings. |
| Investigation of Clinical and Laboratory Findings of 40-49-Year-Old Patients with Fatty Pancreas by Magnetic Resonance Imaging and Evaluation of the Potential Relationship with Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD).
A significant association was found between pancreatic steatosis and metabolic risk factors such as diabetes, obesity, insulin resistance, and MASLD. MRI-based quantification provided accurate detection, supporting its value as the most reliable imaging modality for assessing pancreatic fat. Lifestyle interventions such as weight loss and physical activity may help mitigate pancreatic steatosis and related metabolic consequences. Further studies are needed to clarify causality and underlying pathways, such as lipotoxicity, inflammation, and β-cell dysfunction. |
| Plasma Proteomics Identifies Potential Pancreatic Cancer Risk Indicators in Type 2 Diabetes.
Although validation in a larger cohort is necessary, the analysis highlights differences in plasma protein profiles among patients. This study was done to provide a meaningful indicator for early plasma detection of pancreatic cancer in diabetic patients. |
| Predicting New-Onset Diabetes Following Acute Pancreatitis: The CAPS Score.
A score using readily available clinical information at index admission predicts diabetes mellitus following acute pancreatitis. This CAPS tool will need to be validated and refined in large cohorts such as the Type 1 Diabetes in Acute Pancreatitis Consortium (T1DAPC). |
| Presentation, Management, and Outcomes of Cyst-Associated Pancreatic Cancer versus Classic Pancreatic Ductal Adenocarcinoma.
CA-PC has a better prognosis than PDAC in early stages but not in advanced disease, offering important insights for therapeutic strategies. |
| Pancreatology |
| Association between pancreatic enzyme replacement therapy and mortality in pancreatic cancer: a matched case-control study.
There is an overall decrease in mortality among PERT-users compared to non-users. The results may be overly optimistic due to potential confounding factors related to patient selection, and randomized controlled studies are needed to confirm these effects. |
| Association of the C-reactive protein-to-albumin-to-lymphocyte index with severe acute pancreatitis: A single-center retrospective study of 5,016 patients.
Lower admission CALLY is a predictor of higher SAP risk, outperforming traditional inflammatory markers. It could serve as an early indicator for identifying high-risk patients. |
| Contrast-enhanced harmonic endoscopic ultrasonography (EUS)-guided tissue acquisition significantly improves diagnostic yield for small liver metastases derived from pancreatic cancer: a prospective study.
The present study demonstrates the usefulness and high accuracy of C-EUS-TA for diagnosis of suspected liver metastases, particularly small lesions measuring ≤5 mm. Thus, when confirmation of small liver metastases using conventional imaging is difficult, C-EUS-TA may be useful for histological diagnosis. |
| Gallstone Pancreatitis: Clinical outcomes and economic impact at a tertiary UK Hepatobiliary centre.
Readmission-related expenditure, largely preventable with timely surgery, represents a key target for intervention. Prioritising early cholecystectomy, particularly within 121 days of index admission, may substantially reduce the financial burden and improve patient outcomes across the NHS. |
| Patterns of treatment and survival in borderline resectable and locally advanced pancreatic cancer.
Treatment for pancreatic cancer with major arterial involvement has shifted towards an increased use of multi-agent chemotherapy and surgical resection, with an associated improved overall survival. |
Plenty of the editorials are available as full text through the publisher website using the provided link
| Am J Clin Nutr |
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| Dietary fats, blood lipids and atherosclerotic cardiovascular disease: time for food-based approach? |
| Sweet-liking: a concept useful to psychophysics, but is it useful for dietary guidance? |
misc publications eg case reports, tools of the trade, images of the month, etc…
| J Crohns Colitis |
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| Guselkumab-mediated marked improvement in a case of refractory ulcerative colitis resistant to mirikizumab: evidence for switching between IL-23p19 inhibitors. |
| Liver Transpl |
| Anonymous living liver donation in children: Broad indications, broader impact. |
| Fellows' Corner. |
| Intracardiac thrombosis during liver transplantation: A 22-year single-institution cohort study. |
| Letter to the editor: Is the SRTR metric "Survival on the Waitlist" still useful in the age of machine perfusion and short liver transplant wait times? |
| RAPID progress: Living-donor liver transplantation for unresectable colorectal liver metastases. |
| Reply: Is the SRTR metric "Survival on the Waitlist" still useful in the age of machine perfusion and short liver transplant wait times? |
| Rethinking the use of immunotherapy post-liver transplantation: Standardized protocols with low risk of rejection. |
| Pancreas |
| Commentary on "Lifetime Smoking History and Marijuana Co-use in Patients With Alcohol-related Acute Pancreatitis". |
| Disparities in Chronic Pancreatitis Care in Appalachian Kentucky. |
| Late Cholangitis After Pancreatoduodenectomy due to Ischemic Stricture of the Jejunal Loop. A Long-term Complication due to the Terminal Vascularization of the Jejunal Loop. |
| Letter to "Significance of Pancreatic Steatosis as a Predictor of New-Onset Diabetes Mellitus Following Pancreatectomy". |
| Quadrant-Necrosis-Infection (QNI) Score Predicts Clinical Outcomes Following Endoscopic Drainage of Peripancreatic Fluid Collections in a Resource-Limited, Plastic-Stent-Predominant Setting: A preliminary Retrospective Study. |
| Refining Prognostic Assessment in Acute Pancreatitis: A Vision for Integrating Clinical and Social Determinants. |
| Research Spotlight. |